Yoshiharu Higuchi Selected Research

Phosphotransferases (Kinase)

7/2007	Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer.
6/2004	Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
6/2003	The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
2/2003	Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.

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Yoshiharu Higuchi Research Topics

Disease

14	Atrial Fibrillation 02/2024 - 04/2012
13	Myocardial Infarction 01/2023 - 08/2006
13	Heart Failure 01/2022 - 10/2004
11	Hemorrhage 01/2023 - 01/2019
7	Thrombosis (Thrombus) 01/2024 - 01/2016
6	Hypertrophy 01/2008 - 01/2002
5	Infections 05/2023 - 01/2002
5	Cardiomegaly (Heart Hypertrophy) 05/2007 - 01/2002
4	Stroke (Strokes) 01/2022 - 04/2020
4	Embolism (Embolus) 12/2021 - 01/2018
3	ST Elevation Myocardial Infarction 01/2023 - 10/2021
3	Inflammation (Inflammations) 08/2022 - 01/2020
3	Acute Coronary Syndrome 10/2021 - 09/2017
3	Neointima 08/2021 - 09/2017
2	Peripheral Arterial Disease 01/2024 - 01/2022
2	Cardiomyopathies (Cardiomyopathy) 09/2023 - 07/2023
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 01/2017
2	Chronic Renal Insufficiency 01/2022 - 12/2020
2	Ischemia 07/2020 - 02/2003
2	Death (Near-Death Experience) 07/2020 - 01/2017
2	Hyperplasia 09/2017 - 01/2016
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 07/2007 - 10/2004
2	Ventricular Remodeling 08/2006 - 12/2003
1	Cerebral Infarction 01/2024
1	Disease Progression 01/2024
1	Second Primary Neoplasms (Neoplasms, Second) 09/2023
1	Neoplasms (Cancer) 09/2023
1	Edema (Dropsy) 07/2023
1	Ventricular Tachycardia 07/2023
1	Splenic Infarction 05/2023
1	Endocarditis 05/2023
1	Embolic Stroke 10/2022
1	Chest Pain (Chest Pains) 09/2022
1	Body Weight (Weight, Body) 03/2022
1	Abdominal Obesity 01/2022
1	Obesity 01/2022
1	Ulcer 10/2021
1	Constrictive Pericarditis 04/2021
1	Pericardial Effusion 04/2021
1	Torsades de Pointes (Torsade de Pointes) 01/2021
1	Adenocarcinoma 01/2021
1	Adenocarcinoma of Lung 01/2021
1	Pathologic Constriction (Stenosis) 01/2021
1	Cardiotoxicity 01/2021
1	Anemia 12/2020

Drug/Important Bio-Agent (IBA)

10	AnticoagulantsIBA 01/2023 - 01/2019
6	MAP Kinase Kinase Kinase 5IBA 01/2008 - 01/2002
4	Phosphotransferases (Kinase)IBA 07/2007 - 02/2003
4	NF-kappa B (NF-kB)IBA 02/2005 - 01/2002
4	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 02/2005 - 01/2002
3	Everolimus FDA Link 01/2023 - 12/2021
3	Hemoglobins (Hemoglobin)IBA 03/2022 - 08/2008
3	omega-Chloroacetophenone (Mace)IBA 01/2021 - 01/2017
3	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2021 - 08/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2002 - 01/2002
2	PolymersIBA 01/2023 - 01/2023
2	Prasugrel Hydrochloride FDA Link 01/2022 - 12/2020
2	pro-brain natriuretic peptide (1-76)IBA 01/2021 - 07/2020
2	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 12/2020 - 01/2019
2	C-Reactive ProteinIBA 07/2020 - 01/2020
2	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 04/2020 - 01/2019
2	MetalsIBA 09/2017 - 10/2014
2	Angiotensin IIIBA 10/2004 - 01/2002
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2004 - 01/2002
2	Endothelin-1 (Endothelin 1)IBA 06/2004 - 01/2002
2	NF-KappaB Inhibitor alphaIBA 06/2003 - 01/2002
1	CholesterolIBA 01/2024
1	Fluorocarbon PolymersIBA 01/2024
1	Tyrosine Kinase InhibitorsIBA 09/2023
1	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2023
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 09/2023
1	TenascinIBA 09/2023
1	Cabergoline FDA LinkGeneric 07/2023
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2023
1	Methicillin (Metin)FDA Link 05/2023
1	Warfarin (Coumadin)FDA LinkGeneric 10/2022
1	BNT162 VaccineIBA 09/2022
1	mRNA VaccinesIBA 09/2022
1	Prednisolone (Predate)FDA LinkGeneric 08/2022
1	CreatinineIBA 03/2022
1	3-Iodobenzylguanidine (Iobenguane)IBA 01/2022
1	Mineralocorticoid Receptor AntagonistsIBA 01/2022
1	Eplerenone (Inspra)FDA LinkGeneric 01/2022
1	LipidsIBA 08/2021
1	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 04/2021
1	osimertinibIBA 01/2021
1	EnzymesIBA 01/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2021

Therapy/Procedure

14	Stents 01/2024 - 10/2014
11	Therapeutics 01/2022 - 07/2007
7	Percutaneous Coronary Intervention 01/2022 - 02/2013
5	Drug-Eluting Stents 01/2024 - 01/2016
3	Catheter Ablation 11/2019 - 04/2012
2	Drug Tapering 01/2021 - 04/2020
1	Lasers (Laser) 02/2024
1	Drug Therapy (Chemotherapy) 09/2023
1	Cesarean Section (Caesarean Section) 07/2023
1	Catheters 07/2023
1	Thoracotomy 05/2023
1	Radiotherapy 01/2021